IMR Press / FBE / Volume 4 / Issue 6 / DOI: 10.2741/e528

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The JNK signalling transduction pathway in the brain

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1 Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, 20156, Italy

Academic Editor: Roberta Ghidoni

Front. Biosci. (Elite Ed) 2012, 4(6), 2110–2120; https://doi.org/10.2741/e528
Published: 1 January 2012
Abstract

Among the numerous intracellular signalling pathways that control brain development and pathogenesis c-Jun N-terminal kinases have a leading role in the Central Nervous System. JNKs regulate a wide range of processes in brain development, plasticity, repair/regeneration, neuronal death and neuroinflammation. Indeed, accumulating evidence underline the potential of JNK targeted molecules towards the treatment of neurodegenerative disorders. The focus of the presenting review is to provide an overview of the reported data linking JNKs to brain function and dysfunction.

Keywords
JNK
Brain development
Plasticity
Neurodegeneration
Excitotoxicity
Stroke
AD
PD
Neuroinflammation
Tumor
Pain
Scaffold protein
Review
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