IMR Press / FBE / Volume 4 / Issue 4 / DOI: 10.2741/e473

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Current concepts on the immunopathogenesis of inflammatory bowel disease

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1 Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Davis Building Room 4066, Los Angeles, CA 90048, USA
2 Department of Medicine, Division of Digestive Diseases, University of California, 200 Medical Plaza Suite 365A, Los Angeles, CA 90095, USA

*Author to whom correspondence should be addressed.

Academic Editor: Zaher Radi

Front. Biosci. (Elite Ed) 2012, 4(4), 1451–1477;
Published: 1 January 2012
(This article belongs to the Special Issue Inflammatory bowel disease -1)

Inflammatory bowel disease (IBD) is comprised of both ulcerative colitis (UC) and Crohn’s disease (CD) and is a chronic inflammatory disorder that results from a dysregulated immune response in genetically susceptible individuals. Data from genome-wide association studies (GWAS) have identified approximately 70 genetic loci that confer susceptibility to CD and over 30 loci that are associated with UC. These genetic loci guide the understanding of the molecular mechanisms of these gene products and reveal that alterations in the immune response underlie the pathophysiology of IBD. This review highlights critical areas in the microbiome, innate immune response, and the adaptive immune response that lead to the chronic mucosal inflammation typically seen in IBD.

Crohn’s Disease
Ulcerative Colitis
Innate Immunity
Adaptive Immunity
BacterialHost Interactions
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