IMR Press / FBE / Volume 4 / Issue 4 / DOI: 10.2741/e474

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


MicroRNAs and other mechanisms regulate interleukin-17 cytokines and receptors

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1 Department of Pharmacology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA

*Author to whom correspondence should be addressed.

Academic Editor: Xiao-Feng Yang

Front. Biosci. (Elite Ed) 2012, 4(4), 1478–1495;
Published: 1 January 2012
(This article belongs to the Special Issue Homeostasis and therapeutical potential of CD4)

Interleukin-17 cytokines are a family of proinflammatory cytokines. Our current studies found: i) IL17 cytokines are not ubiquitously expressed, but several receptors and TRAF3IP2 are ubiquitously expressed in tissues with a few exceptions; ii) heart and vascular tissue are in the second tier of readiness to respond to IL-17 cytokine stimulation; iii) alternative transcription starting sites and alternative spliced isoforms are found in IL-17 cytokine and receptor transcripts; iv) higher hypomethylation status is associated with higher expressions of IL-17 receptors; v) the binding sites of several RNA binding proteins are found in the 3’UTRs of the mRNAs of IL-17 cytokines and receptors; and vi) numerous microRNA binding sites are statistically equivalent to that of experimentally verified microRNAsmRNA interactions in the 3’UTRs of IL-17 cytokine and receptor mRNAs. These results suggest that mechanisms including alternative promoters, alternative splicing, RNA binding proteins, and microRNAs regulate the structures and expressions of IL-17 cytokines and receptors. These results provide an insight into the roles of IL-17 in mediating inflammation and immunity.

interleukin-17 Cytokines
Interleukin-17 Receptors
Gene Expression
mRNA Stability
Vascular Inflammation
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