IMR Press / FBE / Volume 4 / Issue 1 / DOI: 10.2741/e368

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Peripheral cholesterol, metabolic disorders and Alzheimer’s disease

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1 Center for Molecular Biology Severo Ochoa CSIC-UAM, Madrid, Spain
2 VIB Department of Molecular and Developmental Geneticsm, Belgium
3 Catholic University of Leuven, Department of Human Genetics, Leuven, Belgium

*Author to whom correspondence should be addressed.

Academic Editor: Agata Copani

Front. Biosci. (Elite Ed) 2012, 4(1), 181–194; https://doi.org/10.2741/e368
Published: 1 January 2012
(This article belongs to the Special Issue Alzheimer's disease)
Abstract

Strong correlations have been made between high levels of blood cholesterol and the risk to suffer Alzheimer’s disease (AD). The question arises on how a peripheral event contributes to a disease that so severely affects the integrity and function of the Central Nervous System. Hypercholesterolemia has been also associated to peripheral metabolic disorders like diabetes, obesity or atherosclerosis that, in turn, predispose to AD. Here we review data, which point to alterations in blood cholesterol levels as a link between these metabolic disorders and AD. We describe and discuss common, cholesterol-related, molecular mechanisms and strategies to fight these conditions that, altogether, constitute a major cause of death in our societies.

Keywords
Hypercholesterolemia
Diabetes
Obesity
Atherosclerosis
Alzheimer’s Disease
Insulin
Leptin
Brain Blood Barrier
Review
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