IMR Press / FBE / Volume 3 / Issue 4 / DOI: 10.2741/E353

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Oxidative stress in primary open-angle glaucoma
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1 Schlosspark-Klinik, Department of Ophthalmology, Heubnerweg 2, 14059 Berlin, Germany

*Author to whom correspondence should be addressed.

Academic Editor: Lepsa Zoric

Front. Biosci. (Elite Ed) 2011, 3(4), 1524–1533; https://doi.org/10.2741/E353
Published: 1 June 2011
(This article belongs to the Special Issue Eye and oxidation stres)
Abstract

Glaucoma is the second leading cause of blindness worldwide and is still a mysterium. Despite some risk factors are known, like individually elevated intraocular pressure, myopia, age, genetic factors, as well as vascular risk factors and smoking, the exact mechanism developing a glaucomatous optic neuropathy are still unknown. In the pathogenesis of glaucoma oxidative stress seems to play an important role. The mitochondria have an abnormal DNS and the antioxidative capacity is reduced. In addition, in the anterior segment, e.g. trabecular meshwork as well as in the posterior pole glaucoma patients show an increased oxidative stress. Therefore oxidative stress should be considered in therapeutic approaches to glaucoma patients.

Keywords
Oxidative Stress
Glaucoma
NF-κB
trabecular meshwork
Review
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