Urinary S100A1B and S100BB to predict hypoxic ischemic encephalopathy at term

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Article

Moataza Bashir¹, Alessandro Frigiola², Iman Iskander¹, Hala Mufeed Said¹, Hanna Aboulgar¹, Rosanna Frulio³, Pierluigi Bruschettini³, Fabrizio Michetti⁴, Pasquale Florio⁵, Serena Pinzauti⁵, Raul Abella², Michele Mussap⁶, Diego Gazzolo^3,7,*

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¹ Department of Neonatology, Cairo University, Cairo, Egypt

² Perinatal Research Laboratory Department of Cardiac Surgery, S. Donato Milanese University Hospital, Milan, Italy

³ Department of Pediatrics and Neuroscience G. Gaslini Children’s University Hospital, Genoa, Italy

⁴ Institute of Anatomy and Cell Biology, Catholic University, I-00168 Rome, Italy

⁵ Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

⁶ Biochemical and Clinical Laboratory, San Martino Hospital, Genoa, Italy

⁷ Neonatal Intensive Care Unit, C. Arrigo Children’s Hospital, Alessandria, Italy

Front. Biosci. (Elite Ed) 2009, 1(2), 560–567; https://doi.org/10.2741/E54

Published: 1 June 2009

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Abstract

Urinary S100A1B and S100BB were measured to detect cases at risk of hypoxic-ischemic encephalopathy (HIE) in asphyxiated newborns. We recruited 42 asphyxiated infants and 63 healthy term neonates. S100A1B and S100BB were measured at first urination (time 0) and at 4 (time 1), 8 (time 2), 12 (time 3), 16 (time 4), 20 (time 5), 24 (time 6), 72 (time 7) hours after birth. 20 infants had no/mild HIE with good prognosis (Group A) and 22 had moderate/severe HIE with a greater risk of neurological handicap (Group B). Urine S100A1B and S100BB levels were significantly (P less than 0.0.01, for all) higher at all monitoring time-points in Group B than Group A and controls, but not between Group A and controls. Both S100A1B and S100BB have great sensitivity and specificity for HIE since their first measurement. In conclusion, S100A1B and S100BB are increased in urine collected from asphyxiated newborns who will develop HIE since first urination, and their measurement may be useful to early predict HIE when monitoring procedures are still of no avail.

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Front. Biosci. (Elite Ed) Print ISSN 1945-0494 Electronic ISSN 1945-0508