Cardiorenal Syndrome in Acute Kidney Injury

Dear Colleagues,

The term “Cardiorenal Syndrome” (CRS) includes a scenario of clinical interactions in which cardiac and renal dysfunction coexist. The crosstalk between the heart and the kidney has been clearly established but not fully understood. Many different factors have been shown to be involved in the pathogenesis of CRS. Mechanisms leading to CRS are multi-factorial and involve not only hemodynamic parameters.
Recently, considerable attention has been paid to the role of new alternative mechanisms which may be implicated in the pathogenesis of cardiorenal crosstalk, such as epigenetics, prenatal programming, small non-coding RNA and extracellular vesicles, and their possible role in heart and kidney disease.
Acute kidney injury develops in CRS type 1 due to a rapid worsening of cardiac function, whereas in CRS type 3 it is responsible for acute cardiac damage. In CRS type 5, acute kidney injury and cardiac dysfunction coexist in the setting of systemic disorders, such as sepsis, autoimmune disease and diabetes mellitus. Beyond hemodynamic pathways, other mechanisms have been described to be involved in the pathogenesis of all these syndromes, including the activation of the sympathetic nervous system, innate and adaptive immunity dysregulation, inflammation and impaired balance of reactive oxygen species (ROS) versus nitric oxide (NO) production.
In this Special Issue, we invite original research as well as review articles giving high priority to the following topics:
- Different types of Cardiorenal Syndrome
- Pathophysiology of Cardiorenal Syndrome
- Molecular and cellular mechanisms underlying Cardiorenal Syndrome
- Hemodynamic and non-hemodynamic mechanisms in Cardiorenal Syndrome
- Organ crosstalk between heart and kidney

Dr. Grazia Maria Virzì and Dr. Anna Clementi
Guest Editors

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.