IMR Press / FBL / Volume 9 / Issue 2 / DOI: 10.2741/1358

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

ALG-2, a multifunctional calcium binding protein?
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1 Department of Molecular Cell Biology, Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, 1353 Copenhagen K, Denmark, Novo Nordisk A/S, Dept. of Cancer and ImmunoBiology, Novo Nordisk Park, G8.1.21, 2760 Måløv, Denmark
Academic Editor:Emanuel Strehler
Front. Biosci. (Landmark Ed) 2004, 9(2), 1817–1832;
Published: 1 May 2004
(This article belongs to the Special Issue Calcium homeostasis and calcium signaling in health and disease)

ALG-2 was originally discovered as a pro-apoptotic protein in a genetic screen. Due to its ability to bind calcium with high affinity it was postulated to provide a link between the known effect of calcium in programmed cell death and the molecular death execution machinery. This review article discusses the current knowledge on the structure and potential function of this protein. Several putative binding partners of ALG-2 have been identified hinting to functions of ALG-2 in apoptosis and possibly also in proliferation, endocytosis and transcriptional regulation during development. Gene deletion of the well conserved ALG-2 locus in several genetic model organisms has so far not provided insights into functions and signaling pathways with ALG-2 involvement. Special focus is given to controversial data on expression and localization of ALG-2, which is mainly caused by the use of ALG-2 antibodies with different specificities.

Calcium binding proteins
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