IMR Press / FBL / Volume 26 / Issue 2 / DOI: 10.2741/4897

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Bisphenol A: an endocrine-disruptor compound that modulates the immune response to infections
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1 Departamento de Parasitologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, CP 04510, Ciudad de Mexico, Mexico
2 Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, CP 04510, Ciudad de Mexico, Mexico
3 Laboratorio de Genotoxicología y Mutagenesis Ambiental, Departamento de Ciencias Ambientales, Centro de Ciencias de la Atmosfera, Universidad Nacional Autonoma de Mexico CP 04510, Ciudad de Mexico, Mexico
4 Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 06720, Cd de Mexico, Mexico
5 UIM en Inmunologìa, Hospital de Pediatrìa, CMN S XXI, IMSS, 06720, Cd de Mèxico, Mexico
6 Departamento de Inmunologìa, Instituto de Investigaciones Biomedicas, Universidad Nacional Autònoma de Mèxico, 04510, Cd de Mexico, Mexico
Send correspondence to: Jorge Morales-Montor, Departamento de Inmunologia, Instituto de Investigaciones Biomedicas,Universidad Nacional Autonoma de Mexico, AP 70228, CP 04510, Ciudad de Mexico, Mexico, Tel: 52555-56223158, Fax: 525556223369, E-mail:
Front. Biosci. (Landmark Ed) 2021, 26(2), 346–362;
Published: 1 October 2020
(This article belongs to the Special Issue Enviromental medicine and its impact on human health)

Bisphenol A (BPA) is an endocrine-disruptor compound that exhibits estrogenic activity. BPA is used in the production of materials such as polycarbonate plastics, epoxy resins and dental sealants. Whereas, the endocrine modulating activity of BPA and its effects on reproductive health have been widely studied, its effects on the function of the immune system are poorly characterized. This might be attributable to the different BPA doses used in a diversity of animal models. Moreover, most studies of the effect of BPA on the immune response are limited to in vitro and in vivo studies that have focused primarily on the impact of BPA on the number and proportion of immune cell populations, without evaluating its effects on immune function in response to an antigenic challenge or infectious pathogens. In this review, we discuss the current literature on the effects of BPA on the function of immune system that potentially increases the susceptibility to infections by the virtue of acting as a pro-inflammatory molecule. Thus, it appears that BPA, while by such an impact might be useful in the control of certain disease states that are helped by an inflmmatory response, it can worsen the prognosis of diseases that are adversely affected by inflammation.

Environmental pollution
Environmental medicine
Endocrine disruptors
Bisphenol A
Figure 1
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