† These authors contributed equally.
Academic Editor: Graham Pawelec
Background: Cystic fibrosis transmembrane conductance regulator (CFTR)
has been associated with vascular tone and blood pressure (BP), however, its role
in the genesis of hypertension remains elusive. In the present study, we
investigated the regulating effect of CFTR on angiotensin II (Ang II) -induced
hypertension and defined the molecular role of CFTR in vasoconstriction.
Results: We found that CFTR mRNA and protein expression were
markedly down-regulated in the arteries from Ang II induced hypertensive animals.
During the development of hypertension, BP of Cftr