Volume 26 Issue 12 2021

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Open Access Editorial

Circulating markers in metastatic cancer: new perspectives

Irene A. George, Janani Sambath, Prashant Kumar

Front. Biosci. (Landmark Ed) 2021, 26(12), 1383–1385; https://doi.org/10.52586/5031

Abstract Full Text PDF(58.13KB)

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296

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Open Access Editorial

Amino acids in nutrition, health, and disease

Guoyao Wu

Front. Biosci. (Landmark Ed) 2021, 26(12), 1386–1392; https://doi.org/10.52586/5032

Abstract Full Text PDF(99.76KB)

206

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7

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432

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Open Access Editorial

Current status and perspectives on CAR-T therapy

Ji Woong Kim, Sukmook Lee

Front. Biosci. (Landmark Ed) 2021, 26(12), 1393–1395; https://doi.org/10.52586/5033

Abstract Full Text PDF(780.59KB)

91

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246

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Open Access Original Research

CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca ${}^{\bm{2+}}$ influx and RhoA/Rock pathway in VSMCs

Liyan Zhao, Feng Yuan, Ni Pan, Yun Yu, ... Guanlei Wang

Front. Biosci. (Landmark Ed) 2021, 26(12), 1396–1410; https://doi.org/10.52586/5034

Abstract Full Text PDF(9.01MB)

99

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6

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326

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Open Access Original Research

ARID1A-mutated cervical cancer depends on the activation of YAP signaling

Fei Gao, Peiling Li, Xianchao Kong, Tiefang Song, ... Suiyang Zhou

Front. Biosci. (Landmark Ed) 2021, 26(12), 1411–1421; https://doi.org/10.52586/5035

Abstract Full Text PDF(3.38MB)

91

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362

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Open Access Original Research

Incorporating structural features to improve the prediction and understanding of pathogenic amino acid substitutions

Yao Xiong, Jing-Bo Zhou, Ke An, Wei Han, ... Yun-Dong Wu

Front. Biosci. (Landmark Ed) 2021, 26(12), 1422–1433; https://doi.org/10.52586/5036

Abstract Full Text PDF(2.11MB)

47

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272

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Open Access Original Research

Estrous cycle phase affects myocardial infarction through reactive oxygen species and nitric oxide

Diana Ramírez-Hernández, Pedro López-Sanchez, Martha C. Rosales-Hernández, Salvador Fonseca-Coronado, Jazmín Flores-Monroy

Front. Biosci. (Landmark Ed) 2021, 26(12), 1434–1443; https://doi.org/10.52586/5037

Abstract Full Text PDF(2.70MB)

77

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216

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Open Access Original Research

Molecular differences between stable idiopathic pulmonary fibrosis and its acute exacerbation

Junho Kang, Hye Ju Yeo, Yun Hak Kim, Woo Hyun Cho

Front. Biosci. (Landmark Ed) 2021, 26(12), 1444–1452; https://doi.org/10.52586/5038

Abstract Full Text PDF(1.96MB)

107

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336

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Open Access Original Research

Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia

Ahmed M. Alsehli, Gull Rukh, Laura E. Clemensson, Diana-Maria Ciuculete, ... Helgi B. Schiöth

Front. Biosci. (Landmark Ed) 2021, 26(12), 1453–1463; https://doi.org/10.52586/5039

(This article belongs to the Special Issue Circadian Rhythms in Health and Disease)

Abstract Full Text PDF(276.76KB)

88

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334

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Open Access Original Research

Influence of short-term cooling on the performance of superelastic and thermally-treated rotary NiTi files tested in dynamic cyclic fatigue model

Ammar AbuMostafa, Mohammed Alfadaghem

Front. Biosci. (Landmark Ed) 2021, 26(12), 1464–1469; https://doi.org/10.52586/5040

(This article belongs to the Special Issue NiTi Rotary Instruments in Endodontics)

Abstract Full Text PDF(847.43KB)

107

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1

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224

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Open Access Original Research

Homotopy of resting-state functional connectivity correlates with psychological distress in adolescent and young adult cancer patients

Jianfei Xie, Lijun Li, Lu Wang, Panpan Xiao, ... Andy SK Cheng

Front. Biosci. (Landmark Ed) 2021, 26(12), 1470–1479; https://doi.org/10.52586/5041

Abstract Full Text PDF(6.86MB)

50

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157

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Open Access Original Research

Phospho-Smad3 signaling is predictive biomarker for hepatocellular carcinoma risk assessment in primary biliary cholangitis patients

Naohiro Nakamura, Katsunori Yoshida, Rinako Tsuda, Miki Murata, ... Makoto Naganuma

Front. Biosci. (Landmark Ed) 2021, 26(12), 1480–1492; https://doi.org/10.52586/5042

Abstract Full Text PDF(5.67MB)

70

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275

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Open Access Original Research

Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates

Celine Boschi, Marion Le Bideau, Julien Andreani, Sarah Aherfi, ... Bernard La Scola

Front. Biosci. (Landmark Ed) 2021, 26(12), 1493–1502; https://doi.org/10.52586/5043

(This article belongs to the Special Issue Vaccine and anti-viral drug development for SARS-CoV2)

Abstract Full Text PDF(1.69MB)

63

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2

Citations

265

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Open Access Original Research

Rapid motor progression of Parkinson’s disease associates with clinical and genetic variants

Ling-Xiao Cao, Yong Jiang, Ying-Shan Piao, Yue Huang

Front. Biosci. (Landmark Ed) 2021, 26(12), 1503–1512; https://doi.org/10.52586/5044

Abstract Full Text PDF(1.03MB)

59

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6

Citations

231

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Open Access Original Research

Initiation of oogenesis and meiosis in the fetal ovary depends on Dennd1a-mediated production of Wnt5a and retinoic acid from the somatic niches

Jingjing Shi, Qun Niu, Qing Gao, Jiang Fu, Jinlong Ma

Front. Biosci. (Landmark Ed) 2021, 26(12), 1513–1524; https://doi.org/10.52586/5045

Abstract Full Text PDF(4.66MB)

52

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1

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202

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Open Access Original Research

Choline supplementation influences ovarian follicular development

Xiaoshu Zhan, Lauren Fletcher, Serena Dingle, Enzo Baracuhy, ... Julang Li

Front. Biosci. (Landmark Ed) 2021, 26(12), 1525–1536; https://doi.org/10.52586/5046

Abstract Full Text PDF(1.41MB)

243

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1

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623

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Open Access Original Research

Machine learning–based prediction of heat pain sensitivity by using resting-state EEG

Fu-Jung Hsiao, Wei-Ta Chen, Li-Ling Hope Pan, Hung-Yu Liu, ... Shuu-Jiun Wang

Front. Biosci. (Landmark Ed) 2021, 26(12), 1537–1547; https://doi.org/10.52586/5047

(This article belongs to the Special Issue Explainable AI and Deep Learning Applied in Medical Field)

Abstract Full Text PDF(23.57MB)

149

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264

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Open Access Original Research

Maternal mindful eating as a target for improving metabolic outcomes in pregnant women with obesity

Karen L Lindsay, Jasper Most, Kerrie Buehler, Maryam Kebbe, ... Leanne M Redman

Front. Biosci. (Landmark Ed) 2021, 26(12), 1548–1558; https://doi.org/10.52586/5048

(This article belongs to the Special Issue The Effects of Maternal Nutrition on Metabolism of Infants and Children)

Abstract Full Text PDF(363.40KB)

62

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2

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213

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Open Access Original Research

Genome-wide signatures in flax pinpoint to adaptive evolution along its ecological gradient

Demissew Sertse, Frank M. You, Sylvie Cloutier

Front. Biosci. (Landmark Ed) 2021, 26(12), 1559–1571; https://doi.org/10.52586/5049

(This article belongs to the Special Issue Leveraging Ecological and Genomic Signatures of Polygenic Adaptation)

Abstract Full Text PDF(3.93MB)

65

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3

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236

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Open Access Original Research

Hepatoprotective effect of genistein against dimethylnitrosamine-induced liver fibrosis in rats by regulating macrophage functional properties and inhibiting the JAK2/STAT3/SOCS3 signaling pathway

Ying Xu, Dingqi Zhang, Hailin Yang, Yu Liu, ... Wei Liu

Front. Biosci. (Landmark Ed) 2021, 26(12), 1572–1584; https://doi.org/10.52586/5050

Abstract Full Text PDF(4.79MB)

213

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6

Citations

597

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Open Access Original Research

Sex-specific differences in the gut microbiota and fecal metabolites in an adolescent valproic acid-induced rat autism model

You-Yu Gu, Ying Han, Jing-Jing Liang, Ya-Nan Cui, ... Jiong Qin

Front. Biosci. (Landmark Ed) 2021, 26(12), 1585–1598; https://doi.org/10.52586/5051

Abstract Full Text PDF(2.03MB)

187

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3

Citations

513

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Open Access Original Research

Comparison and evaluation of acid reflux esophagitis animal models

Yanping Tang, Lei Liu, Xi Liu, Shuhong Li, ... Rui Wang

Front. Biosci. (Landmark Ed) 2021, 26(12), 1599–1606; https://doi.org/10.52586/5052

Abstract Full Text PDF(2.10MB)

72

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1

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190

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Open Access Original Research

Potential links between COVID-19-associated pulmonary aspergillosis and bronchiectasis as detected by high resolution computed tomography

Elisa Baratella, Erik Roman-Pognuz, Verena Zerbato, Pierluca Minelli, ... Stefano Di Bella

Front. Biosci. (Landmark Ed) 2021, 26(12), 1607–1612; https://doi.org/10.52586/5053

(This article belongs to the Special Issue Cytokine storm in lung diseases)

Abstract Full Text PDF(5.59MB)

92

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13

Citations

333

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Open Access Review

What is the role of Achromobacter species in patients with cystic fibrosis?

Susanna Esposito, Giovanna Pisi, Valentina Fainardi, Nicola Principi

Front. Biosci. (Landmark Ed) 2021, 26(12), 1613–1620; https://doi.org/10.52586/5054

(This article belongs to the Special Issue Cystic fibrosis lung disease: from basic research to clinical issues)

Abstract Full Text PDF(109.70KB)

196

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4

Citations

357

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Open Access Review

CARD9 as a potential therapeutic target in lung cancer

Ruanmei Sheng, Zhiwen Yang

Front. Biosci. (Landmark Ed) 2021, 26(12), 1621–1626; https://doi.org/10.52586/5055

(This article belongs to the Special Issue Cancer Metabolism and the Tumor Microenvironment)

Abstract Full Text PDF(805.77KB)

84

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1

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244

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Open Access Review

Role of misfolding in rare enzymatic deficits and use of pharmacological chaperones as therapeutic approach

Gioena Pampalone, Silvia Grottelli, Leonardo Gatticchi, Emilia Maria Lombardi, ... Barbara Cellini

Front. Biosci. (Landmark Ed) 2021, 26(12), 1627–1642; https://doi.org/10.52586/5056

(This article belongs to the Special Issue Twenty-five years at the frontiers of knowledge: a quarter-century of "Frontiers in Bioscience")

Abstract Full Text PDF(1.21MB)

138

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4

Citations

342

Views
Open Access Review

Impact of stress and hypertension on the cerebrovasculature

Nada Elsaid, Ahmed Saied, Heba Kandil, Ahmed Soliman, ... Ayman El-Baz

Front. Biosci. (Landmark Ed) 2021, 26(12), 1643–1652; https://doi.org/10.52586/5057

Abstract Full Text PDF(791.43KB)

305

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11

Citations

824

Views
Open Access Review

Puerarin—an isoflavone with beneficial effects on bone health

Bartosz Kulczyński, Anna Gramza-Michałowska, Joanna Suliburska, Andrzej Sidor

Front. Biosci. (Landmark Ed) 2021, 26(12), 1653–1667; https://doi.org/10.52586/5058

(This article belongs to the Special Issue Innovative strategies enhancing nutraceutical properties of vegetables, and aromatic-medicinal plants and mushrooms)

Abstract Full Text PDF(406.20KB)

159

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9

Citations

428

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Open Access Review

Pathways in small cell lung cancer and its therapeutic perspectives

Pingali M. Shivapriya, Anirudh Singh, Priyanshu Pandey, Nandini Chhabra, ... Sintu Kumar Samanta

Front. Biosci. (Landmark Ed) 2021, 26(12), 1668–1678; https://doi.org/10.52586/5059

Abstract Full Text PDF(1.29MB)

236

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4

Citations

630

Views
Open Access Review

Cerebrospinal fluid as a medium of liquid biopsy in the management of patients with non-small-cell lung cancer having central nervous system metastasis

Chi-Lu Chiang, Hsu-Ching Huang, Yung-Hung Luo, Chao-Hua Chiu

Front. Biosci. (Landmark Ed) 2021, 26(12), 1679–1688; https://doi.org/10.52586/5060

(This article belongs to the Special Issue Lung cancer—recent advances in classification, diagnosis, basic research and therapy)

Abstract Full Text PDF(644.90KB)

74

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3

Citations

225

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Open Access Review

Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target

Di Long, Kai Chen, Yinmo Yang, Xiaodong Tian

Front. Biosci. (Landmark Ed) 2021, 26(12), 1689–1696; https://doi.org/10.52586/5061

(This article belongs to the Special Issue Novel Approaches to Cancer Diagnosis and Therapy)

Abstract Full Text PDF(980.25KB)

87

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3

Citations

252

Views
Open Access Review

Influence of sterilization procedures on the physical and mechanical properties of rotating endodontic instruments: a systematic review and network meta-analysis

Mario Dioguardi, Claudia Arena, Diego Sovereto, Riccardo Aiuto, ... Lorenzo Lo Muzio

Front. Biosci. (Landmark Ed) 2021, 26(12), 1697–1713; https://doi.org/10.52586/5062

(This article belongs to the Special Issue NiTi Rotary Instruments in Endodontics)

Abstract Full Text PDF(514.28KB)

222

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2

Citations

404

Views
Open Access Review

Advances in the knowledge of adaptive mechanisms mediating abiotic stress responses in Camellia sinensis

Yujun Sun, Juan Zhou, Jiansheng Guo

Front. Biosci. (Landmark Ed) 2021, 26(12), 1714–1722; https://doi.org/10.52586/5063

Abstract Full Text PDF(336.41KB)

240

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7

Citations

397

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Open Access Review

The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic

George J. Kontoghiorghes, Stella Fetta, Christina N. Kontoghiorghe

Front. Biosci. (Landmark Ed) 2021, 26(12), 1723–1736; https://doi.org/10.52586/5064

(This article belongs to the Special Issue Twenty-five years at the frontiers of knowledge: a quarter-century of "Frontiers in Bioscience")

Abstract Full Text PDF(968.51KB)

159

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8

Citations

501

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Open Access Mini-Review

Role of the store-operated Ca ${}^{\bm{2+}}$ channel in ATP-induced Ca ${}^{\bm{2+}}$ signalling in mesenchymal stem cells and regulation of cell functions

Lu Wang, Sébastien Roger, Xuebin B Yang, Lin-Hua Jiang

Front. Biosci. (Landmark Ed) 2021, 26(12), 1737–1745; https://doi.org/10.52586/5065

(This article belongs to the Special Issue Twenty-five years at the frontiers of knowledge: a quarter-century of "Frontiers in Bioscience")

Abstract Full Text PDF(341.21KB)

83

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4

Citations

235

Views
Open Access Rapid Report

Speech depression recognition based on attentional residual network

Xiaoyong Lu, Daimin Shi, Yang Liu, Jingyi Yuan

Front. Biosci. (Landmark Ed) 2021, 26(12), 1746–1759; https://doi.org/10.52586/5066

(This article belongs to the Special Issue Synesthesia, hallucination and mental disorders)

Abstract Full Text PDF(6.85MB)

103

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8

Citations

273

Views
Open Access Case Report

Spine surgery and fat embolism syndrome. Defining the boundaries of medical accountability by hospital autopsy

Davide Radaelli, Martina Zanon, Monica Concato, Paolo Fattorini, ... Stefano D’Errico

Front. Biosci. (Landmark Ed) 2021, 26(12), 1760–1768; https://doi.org/10.52586/5067

(This article belongs to the Special Issue Innovation in Forensic Pathology and Forensic Genetics)

Abstract Full Text PDF(2.35MB)

55

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1

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188

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Front. Biosci. (Landmark Ed) Print ISSN 2768-6701 Electronic ISSN 2768-6698