- Academic Editors
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Background: The purpose of this study was to determine the detailed
characteristics of dizziness in patients with de novo Parkinson’s
disease (PD) and the clinical implications of dizziness. Methods:
Ninety-three people with de novo PD were enrolled between July 2017 and
August 2022 for this retrospective study. Using each representative scale,
various motor and non-motor symptoms were assessed. In addition, clinical
manifestations of dizziness in those patients, including its presence, type,
frequency, and duration of occurrence, were investigated. Results:
Thirty-nine patients with de novo PD reported dizziness, with presyncope
being the most common (38%). The most common frequency was several times a week
(51%). The most common duration was a few seconds (67%). Multivariable logistic
regression analysis showed that dizziness was more common in women than in men
{odds ratio (OR): 3.3601, 95% confidence interval (CI): 1.0820–10.4351,
p = 0.0361}. Dizziness was significantly related to non-motor symptoms
of low global cognition (OR: 0.8372, 95% CI: 0.7285–0.9622, p =
0.0123) and severe autonomic dysfunction (OR: 1.1112, 95% CI: 1.0297–1.1991,
p = 0.0067). A post-hoc analysis revealed that dizziness was only
associated with cardiovascular dysautonomia (adjusted OR: 10.2377, 95% CI:
3.3053–31.7098, p