IMR Press / JIN / Volume 22 / Issue 2 / DOI: 10.31083/j.jin2202037
Open Access Original Research
Relationship between the Consciousness State and the Default Mode Network in Traumatic Brain Injury
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1 Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 705-717 Daegu, Republic of Korea
2 Department of Neurosurgery, College of Medicine, Yeungnam University, 705-717 Daegu, Republic of Korea
*Correspondence: (Min Kyeong Cho)
J. Integr. Neurosci. 2023, 22(2), 37;
Submitted: 28 July 2022 | Revised: 31 October 2022 | Accepted: 4 November 2022 | Published: 16 February 2023
(This article belongs to the Special Issue Disorders of Consciousness: From Pathophysiology to Treatment)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Introduction: This study investigated the relationship between Coma Recovery Scale-Revised (CRS-R) and the neural networks between the medial prefrontal cortex (mPFC) and precuneus (PCun)/posterior cingulate cortex (PCC) in disorders of consciousness (DOC) patients with a traumatic brain injury (TBI) using diffusion tensor tractography (DTT). Measures: Twenty-five consecutive patients with TBI admitted to the rehabilitation department of a university hospital were enrolled in this study. The Coma Recovery Scale-Revised (CRS-R) was used to evaluate the consciousness state. The pathway of the neural networks between the mPFC and the PCun (mPFC-PCun DMN)/PCC (mPFC-PCC DMN) were reconstructed using DTT. Fractional anisotropy (FA) and the tract volume (TV) were obtained to assess the diffusion tensor imaging parameters. Results: The CRS-R score had strong positive correlations with the FA value and TV of the mPFC-PCun DMN (p < 0.05), while it showed a moderate positive correlation with the TV of the mPFC-PCC DMN (p < 0.05). In addition, the FA value of the mPFC-Pcun DMN showed that it could explain the variability in the CRS-R score. Conclusions: The close correlation was noted between the consciousness state and the mPFC-PCun DMN and mPFC-PCC DMN in DOC patients with TBI. On the other hand, the mPFC-PCun DMN appeared to be more closely correlated with the consciousness state than the mPFC-PCC DMN.

traumatic brain injury
Coma Recovery Scale-Revised
default mode network
diffusion tensor tractography
disorders of consciousness
2021R1A2B5B01001386/National Research Foundation of Korea (NRF)
Fig. 1.
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