IMR Press / JIN / Volume 22 / Issue 2 / DOI: 10.31083/j.jin2202038
Open Access Review
The Influence of the Gut Microbiota on Alzheimer's Disease: A Narrative Review
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1 The Second Affiliated Hospital of Dalian Medical University, Dalian Medical University, 116027 Dalian, Liaoning, China
2 Department of Anatomy, College of Basic Medicine, Dalian Medical University, 116044 Dalian, Liaoning, China
3 The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, 116011 Dalian, Liaoning, China
4 Department of Surgery, the Affiliated Zhongshan Hospital of Dalian University, 116001 Dalian, Liaoning, China
*Correspondence: (Xiao-Ying Yuan); (Xu-Gang Wang)
J. Integr. Neurosci. 2023, 22(2), 38;
Submitted: 13 December 2022 | Revised: 13 January 2023 | Accepted: 17 January 2023 | Published: 16 February 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Alzheimer’s disease (AD) is a common neurodegenerative disease that tends to occur in the elderly. The main symptom is hypomnesia. More and more older people are suffering from this disease worldwide. By 2050, 152 million people worldwide are expected to have AD. It is thought that the aggregation of amyloid-beta peptides and hyper-phosphorylated tau tangles contribute to AD. The microbiota-gut-brain (MGB) axis appears as a new concept. The MGB axis is a collection of microbial molecules produced in the gastrointestinal tract that influence the physiological function of the brain. In this review, we discuss how the gut microbiota (GM) and its metabolites affect AD in different ways. Dysregulation of the GM has been shown to be involved in various mechanisms involved in memory and learning functions. We review the current literature on the role of the entero-brain axis in the pathogenesis of AD and its potential role as a future therapeutic target in the treatment and/or prevention of AD.

Alzheimer's disease
human gut microbiota
neurodegenerative disease
NSFC32100928/National Natural Science Foundation of China
2020-BS-201/Liaoning Provincial Natural Science Foundation of China
Fig. 1.
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