IMR Press / FBS / Volume 2 / Issue 1 / DOI: 10.2741/S62

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Microbial polysaccharide: new insights for treating autoimmune diseases
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1 Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Perugia 06122, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Mathijs Bergman

Front. Biosci. (Schol Ed) 2010, 2(1), 256–267;
Published: 1 January 2010
(This article belongs to the Special Issue Modulation of host immune responses by bacterial surface glycan)

The immunosuppressive properties of Glucuronoxylomannnan (GXM), a purified capsular polysaccharide of the opportunistic fungus Cryptococcus neoformans, have been extensively elucidated. GXM can inhibit the function of cells belonging to both the innate and adaptive immune systems, leading to inhibition of proinflammatory responses as well as of autoimmune inflammation.This review focuses on the role of GXM as a novel anti-inflammatory agent and puts in perspective the direct implications of its potential destination to clinical trials.

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