Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
*Author to whom correspondence should be addressed.
Academic Editors: Patrick Vermette, Jonathan Lakey, Rennian Wang, Steven Paraskevas
Interactions between vascular endothelial cells (EC) and materials are central to biomedical applications such as vascular graft endothelialization or vascularization of an engineered tissue substitute. To improve implant success, biomaterial surfaces are designed to modulate EC adhesion and responses. In vivo, EC line all blood vessels; their morphology, function and associated matrix are adapted to and specific for the local microenvironment. To enhance EC adhesion and growth, surface treatments have been developed that modify material surface physico-chemical and mechanical properties. Materials may also be coated with bioactive molecules such as proteins from the matrix, peptides and/or growth factors to study and control EC behaviour. The aim of this review is therefore to give an overview of current knowledge related to EC and their matrix environment in vivo and their responses to synthetic surfaces in vitro.