IMR Press / FBS / Volume 16 / Issue 1 / DOI: 10.31083/j.fbs1601006
Open Access Short Communication
The Relationship between Mitochondrial Genome Mutations in Monocytes and the Development of Obesity and Coronary Heart Disease
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1 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, 119435 Moscow, Russia
2 Medical Institute, Рeoples’ Friendship University of Russia Named after Patrice Lumumba (RUDN University), 117198 Moscow, Russia
*Correspondence: (Taisiya V. Tolstik)
Front. Biosci. (Schol Ed) 2024, 16(1), 6;
Submitted: 10 January 2024 | Revised: 20 February 2024 | Accepted: 23 February 2024 | Published: 13 March 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Metabolic disorders, including obesity, are often accompanied by an increased risk of cardiovascular complications. Monocytes are the common link between obesity and cardiovascular diseases (CVDs). The bias of innate cellular immunity towards pro-inflammatory activation stimulates the development of diseases associated with chronic inflammation, in particular metabolic disorders, including obesity, as well as CVDs. Disorders in the functional state of monocytes and activation of inflammation may be associated with mitochondrial dysfunction. Mutations accumulating in mitochondrial DNA with age may lead to mitochondrial dysfunction and may be considered a potential marker for developing chronic inflammatory diseases. Methods: The present study aimed to study the relationship between mitochondrial heteroplasmy in CD14+ monocytes and cardiovascular risk factors in 22 patients with obesity and coronary heart disease (CHD) by comparing them to 22 healthy subjects. Results: It was found that single-nucleotide variations (SNV) A11467G have a negative correlation with total cholesterol (r = –0.82, p < 0.05), low density lipoproteins (LDL) (r = –0.82, p < 0.05), with age (r = –0.57, p < 0.05) and with mean carotid intima-media thickness (cIMT) (r = –0.43, p < 0.05) and a positive correlation with HDL level (r = 0.71, p < 0.05). SNV 576insC positively correlated with body mass index (BMI) (r = 0.60, p < 0.001) and LDL level (r = 0.43, p < 0.05). SNV A1811G positively correlated with mean cIMT (r = 0.60, p < 0.05). Conclusions: It was revealed that some variants of mitochondrial DNA (mtDNA) heteroplasmy are associated with CVD risk factors. The results demonstrate the potential for using these molecular genetic markers to develop personalized CVD and metabolic disorder treatments.

mtDNA mutations
cardiovascular diseases
# 123030700026-8/Ministry of Science and Higher Education of the Russian Federation—the state task of Petrovsky National Research Centre of Surgery
Fig. 1.
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