IMR Press / FBS / Volume 14 / Issue 2 / DOI: 10.31083/j.fbs1402016
Correction published on, see Frontiers in Bioscience-Scholar 2022, 14(4)
Open Access Review
An Updated Review on The Properties of Melissa officinalis L.: Not Exclusively Anti-anxiety
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1 Department of Analytical and Food Chemistry, Faculty of Pharmacy, Al-Andalus University for Medical Sciences, 35XQ+C2F Tartous, Syria
2 Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, 1110939 Iquique, Chile
3 Facultad de Medicina, Universidad del Azuay, 14-008 Cuenca, Ecuador
4 Department of Plant Production, Faculty of Agronomy, Universidad de Concepción, Avenida Vicente Mendez, 595, 3812120 Chillán, Chile
5 Departamento de Suelos y Recursos Naturales, Facultad de Agronomía, Universidad de Concepción, 4070386 Concepción, Chile
6 Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386 Concepción, Chile
7 Research Institution “Chinese-Tajik Innovation Center for Natural Products” of the National Academy of Sciences of Tajikistan, Ayni str. 299/2, 734063 Dushanbe, Tajikistan
8 Faculty of Science, University of Bamenda, 39 Bamenda-Bambili, Cameroon
9 Department of Pharmacology, University of Free State, 9300 Bloemfontein, South Africa
10 Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, 642109 Tamil Nadu, India
11 Chemical and Biochemical Processing Division, ICAR – Central Institute for Research on Cotton Technology, 400019 Mumbai, India
12 Department of Life Sciences, National University of Kaohsiung, 811 Kaohsiung, Taiwan
13 Phytotherapy Lab (PhT-Lab), Endocrinology Unit, Department of Medicine (DIMED), University of Padova, via Ospedale 105, 35128 Padova, Italy
14 AIROB, Associazione Italiana per la Ricerca Oncologica di Base, 35046 Padova, Italy
*Correspondence: (Javad Sharifi-Rad); (Jen-Tsung Chen); (Raffaele Pezzani); (Farukh Sharopov)
Academic Editor: Gustavo Caetano-Anollés
Front. Biosci. (Schol Ed) 2022, 14(2), 16;
Submitted: 2 February 2022 | Revised: 30 March 2022 | Accepted: 11 April 2022 | Published: 7 June 2022
(This article belongs to the Special Issue Recent Research on Medicinal Plants)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Melissa officinalis L. is a plant of the Lamiaceae family known in numerous countries for its medicinal activities. This plant has been used since ancient times to treat different disorders, including gastrointestinal, cardiovascular, neurological, psychological conditions. M. officinalis contains several phytochemicals such as phenolic acids, flavonoids, terpenoids, and many others at the basis of its pharmacological activities. Indeed, the plant can have antioxidant, anti-inflammatory, antispasmodic, antimicrobial, neuroprotective, nephroprotective, antinociceptive effects. Given its consolidated use, M. officinalis has also been experimented with clinical settings, demonstrating interesting properties against different human diseases, such as anxiety, sleeping difficulties, palpitation, hypertension, depression, dementia, infantile colic, bruxism, metabolic problems, Alzheimer’s disease, and sexual disorders. As for any natural compound, drug, or plant extract, also M. officinalis can have adverse effects, even though the reported events are very rare and the plant can be considered substantially safe. This review has been prepared with a specific research strategy, interrogating different databases with the keyword M. officinalis. Moreover, this work analyzes the properties of this plant updating currently available literature, with a special emphasis on human studies.

Melissa officinalis L.
lemon balm
health properties
clinical trials
Fig. 1.
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