IMR Press / FBS / Volume 14 / Issue 1 / DOI: 10.31083/j.fbs1401005
Open Access Original Research
Complete blood count-derived inflammatory markers and survival in patients with localized renal cell cancer treated with partial or radical nephrectomy: a retrospective single-tertiary-center study
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1 Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, 02-005 Warsaw, Poland
2 Second Department of Gynecology, Medical University of Lublin, 20-090 Lublin, Poland
*Correspondence: lzapala@wum.edu.pl (Łukasz Zapała)
Academic Editor: Neven Zarkovic
Front. Biosci. (Schol Ed) 2022, 14(1), 005; https://doi.org/10.31083/j.fbs1401005
Submitted: 12 November 2021 | Revised: 8 January 2022 | Accepted: 13 January 2022 | Published: 8 February 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

We aimed to compare the predictive value of different inflammatory markers in renal cell carcinoma (RCC). Four hundred ninety-five patients treated with nephrectomy for primary localized or locally advanced RCC between 2010 and 2018 were included in the retrospective analysis. The median follow-up for the entire cohort was 48 months. Based on the preoperative laboratory measurements, patients with higher neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic inflammatory response index (SIRI), systemic immune-inflammation index (SII), neutrophil/erythrocyte ratio (NER), derived neutrophil/lymphocyte ratio (dNLR), and lower lymphocyte/monocyte ratio (LMR) and hemoglobin/platelet ratio (HPR) had worse cancer-specific survival (CSS). In the multivariate analysis tumour stage, grade, age and high SIRI constituted independent factors predicting CSS. The model including SIRI values achieved C-index 0.903 (alternative multivariate models with SII and NLR 0.902 and 0.890, respectively). Age, tumour grade and high NER (or high SIRI/ SII in alternative models) were prognostic for overall survival. Markers of systemic inflammation might provide additional prognostic information (especially SIRI, SII, NLR and NER) and further increase the predictive accuracy of available models in localized and locally advanced renal cell carcinoma. For the first time, we show the prognostic value of neutrophil-to-erythrocyte ratio, which constitutes an independent risk factor of overall survival.

Keywords
Renal cell carcinoma
Biomarkers
Survival analysis
Systemic inflammatory markers
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