The Pathogenesis of Sepsis

Dear Colleagues,

After a pathogen infection, multiple organ dysfunctions cause the host to degenerate which causes by sepsis. Immune cells, platelets, and other host cells enter the inflammatory pathophysiology during pathogen invasion to protect the host. Pathogens are contained and destroyed during this process, which also harms host organs and increases inflammation. The SOFA score, which is determined by how severe organ failure, or APACHE II Scores used to determine the clinical diagnosis of sepsis. The pathogens occasionally produce chemicals to speed up the invasion process. Severity of sepsis may be determined by signal transduction pathways and molecular biomarkers generated by pathogens or the host during the infection process. These findings may provide fresh perspectives on the diagnosis and treatment of sepsis. Risks associated with sepsis with multiple organ dysfunction include morbidity and death. As a result, the prognosis for patients with the sepsis biomarkers may be improved by prompt treatment measures and early detection.

Moreover, clinical features (biomarkers) based methods for diagnosis and treatment of sepsis are mostly clinical and include laboratory testing, such as Systemic Inflammatory Response Syndrome (SIRS). For those syndrome, the hallmarks of inflammation, such as vasodilation, increased microvascular permeability, and leukocyte buildup, are visible in tissues far from the site of the initial injury. State-of-the-art in data oriented construction initiatives aim to establish reliable and robust empirical causality to behavior through comprehensive features-based analyzes.

This Research Topic aims to explore reliable clinical features for diagnosis and treatment or even prognosis through state-of-the-art in data oriented modeling involving wet and dry laboratory techniques, including in vivo in vitro, large data sets, data-mining, brain imaging, inhibitor, alternative medicine, nutrient(s), dietary, life style, exercise or fixed mechanisms, and advance in Sepsis.

Dr.  I‐Shiang Tzeng and Zuowei Pei
Guest Editors

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