Metabolomics in Health and Disease: From Clinical Research to Clinical Testing

Dear Colleagues,

Metabolomics, defined as the comprehensive analysis of small molecules involved in metabolic pathways of living organisms, addresses the complex interplay between the human genome, epigenetic factors, and the microbiome. The impressive growth of publications on metabolomics over the last 22 years (8 PubMed citations in 2000 and 12,746 in 2022) is due to at least three factors: (a) the availability of high-throughput technologies generating large-scale data related to “omics” analysis, including metabolomics; (b) the need to unravel the molecular processes induced by the complex interplay between the human genome and environmental factors; (c) the application of individualized medicine based on the system biology approach. Most published metabolomics based articles consist of experimental in vitro or in vivo studies in animal models and plants, as well as clinical research in human diseases. Regrettably, most discoveries have not yet been translated into the clinical setting. Moving metabolomics research into clinical testing means that metabolomic results must impact clinical decision-making, similar to any other clinical test result. Moreover, quantitative data acquisition is critical, being a prerequisite for clinical decision-making. This special issue encourages the submission of original metabolomics-based studies applied to clinical practice; narrative and systematic reviews are also requested. Our aim is to contribute to reducing the metabolomics translational gap.

Dr. Michele Mussap
Guest Editor

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.