IMR Press / FBL / Special Issues / 1326789875768655874

Cellular response to mitochondrial dysfunction and pathogenic mtDNA mutations

Submission deadline: 31 January 2022
Special Issue Editor
Yau-Huei Wei
Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua City, Taiwan 50046
Interests: Mitochondrial Disease; Mitochondrial DNA Mutation; Stem Cells; iPSC; Metabolic Reprogramming
Special Issue and Collections in IMR journals
Special Issue Information

Dear Colleagues,

Mitochondrial DNA (mtDNA) mutations result in not only inefficient supply of ATP but also increased production of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide in mitochondria of the affected tissues of patients with mitochondrial disease or in elderly subjects. Extensive studies have demonstrated that such an increase of oxidative stress contributes to alterations in the gene expression and activities of enzymes in several metabolic pathways. Several antioxidant enzymes are altered and oxidative damage to DNA, RNA, proteins, and lipids are increased in tissues and cultured cells from mitochondrial disease patients or elderly subjects. The changes at the protein and activity levels of several metabolic pathways result in metabolic reprogramming, which plays an important role in adaptive response and survival of human cells harboring a pathogenic mtDNA mutation. This special issue is focused on the molecular mechanism and consequences of human cell response to pathogenic mtDNA mutation and/or mitochondrial dysfunction.

Prof. Dr. Yau-Huei Wei

Guest Editor

Keywords
Mitochondrial DNA Mutation
Mitochondrial Dysfunction
Mitochondrial Disease
Mitophagy
Oxidative Stress
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.

Published Paper (8 Papers)
Open Access Original Research
Effects of Tolerance-Induced Preconditioning on Mitochondrial Biogenesis in Undifferentiated and Differentiated Neuronal Cells
Jagdeep K. Sandhu, Caroline Sodja, Maria Ribecco-Lutkiewicz, Yu-Ting Wu, ... Marianna Sikorska
Front. Biosci. (Landmark Ed) 2022, 27(4), 115; https://doi.org/10.31083/j.fbl2704115
61
Download
157
Views
Open Access Review
Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity
Jinling Wang, Xiufu Lin, Ningning Zhao, Guanping Dong, ... Junfen Fu
Front. Biosci. (Landmark Ed) 2022, 27(3), 107; https://doi.org/10.31083/j.fbl2703107
80
Download
1
Citations
182
Views
Open Access Review

Tissue transglutaminase (TG2) and mitochondrial function and dysfunction

Thung-S. Lai, Cheng-Jui Lin, Yu-Ting Wu, Chih-Jen Wu
Front. Biosci. (Landmark Ed) 2017, 22(7), 1114–1137; https://doi.org/10.2741/4536
68
Download
7
Citations
58
Views
Open Access Review

Linking telomere loss and mitochondrial dysfunction in chronic disease

Ana Carlota Gonzalez-Ebsen, Niels Gregersen, Rikke K.J. Olsen
Front. Biosci. (Landmark Ed) 2017, 22(1), 117–127; https://doi.org/10.2741/4475
32
Download
16
Citations
23
Views
Open Access Article

Oxidative DNA and mitochondrial DNA change in patients with SLE

Hui-Ting Lee, Tsai-Hung Wu, Chen-Sung Lin, Chyou-Shen Lee, ... Chang-Youh Tsai
Front. Biosci. (Landmark Ed) 2017, 22(3), 493–503; https://doi.org/10.2741/4497
18
Download
8
Citations
10
Views
Open Access Review

Mitochondria in the pathophysiology of Alzheimer’s and Parkinson’s diseases

Isaac G. Onyango, Shaharyar M. Khan, James P. Bennett
Front. Biosci. (Landmark Ed) 2017, 22(5), 854–872; https://doi.org/10.2741/4521
72
Download
72
Citations
68
Views
Open Access Review

Role of mitochondrial DNA variation in the pathogenesis of diabetes mellitus

Soo Heon Kwak, Kyong Soo Park
Front. Biosci. (Landmark Ed) 2016, 21(6), 1151–1167; https://doi.org/10.2741/4447
38
Download
16
Citations
25
Views
Open Access Review

Role of mitochondrial function in cell death and body metabolism

Myung-Shik Lee
Front. Biosci. (Landmark Ed) 2016, 21(6), 1233–1244; https://doi.org/10.2741/4453
31
Download
15
Citations
25
Views
Back to top