Dear Colleagues,

Mitochondrial DNA (mtDNA) mutations result in not only inefficient supply of ATP but also increased production of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide in mitochondria of the affected tissues of patients with mitochondrial disease or in elderly subjects. Extensive studies have demonstrated that such an increase of oxidative stress contributes to alterations in the gene expression and activities of enzymes in several metabolic pathways. Several antioxidant enzymes are altered and oxidative damage to DNA, RNA, proteins, and lipids are increased in tissues and cultured cells from mitochondrial disease patients or elderly subjects. The changes at the protein and activity levels of several metabolic pathways result in metabolic reprogramming, which plays an important role in adaptive response and survival of human cells harboring a pathogenic mtDNA mutation. This special issue is focused on the molecular mechanism and consequences of human cell response to pathogenic mtDNA mutation and/or mitochondrial dysfunction.

Prof. Dr. Yau-Huei Wei

Guest Editor

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.