IMR Press / FBL / Volume 27 / Issue 3 / DOI: 10.31083/j.fbl2703107
Open Access Review
Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity
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1 Department of Endocrinology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 310003 Hangzhou, Zhejiang, China
*Correspondence: (Junfen Fu)
These authors contributed equally.
Academic Editor: Graham Pawelec
Front. Biosci. (Landmark Ed) 2022, 27(3), 107;
Submitted: 27 December 2021 | Revised: 21 February 2022 | Accepted: 7 March 2022 | Published: 18 March 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China. Obesity is closely related to unbalanced cellular energy metabolism. Mitochondria, as the main organelles of energy metabolism, play an important role in the pathophysiology of obesity. Recent researches have revealed that mitochondrial dynamics with constant fission and fusion, can alter mitochondrial structure, organelle connections, ROS production, neuronal activity, and OXPHOS system as well as adipose tissue thermogenesis, which ultimately lead to obesity. In this review, we will update the latest findings about mitochondrial fission/fusion related GTPase proteins and discuss the effects of mitochondrial dynamics in the pathophysiology of obesity.

mitochondrial dynamics
2021YFC2701901/National Key Research and Development Program of China
2016YFC1305301/National Key Research and Development Program of China
81570759/National Natural Science Foundation of China
81270938/National Natural Science Foundation of China
2020XZZX002-22/Fundamental Research Funds for the Central Universities
WKJ-ZJ-1804/Research Fund of Zhejiang Major Medical and Health Science and Technology & National Ministry of Health
LQ20H070003/Zhejiang Provincial Natural Science Foundation of China
LSZ19H070001/Zhejiang Province Natural Sciences Foundation Zhejiang Society for Mathematical Medicine
Fig. 1.
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