Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
A concise overview of circadian timing in Drosophila
The molecular aspects of circadian rhythmicity in Drosophila melanogaster are reviewed, with particular regard to the core of the master oscillator and the light signalling input pathway. The core is schematically represented as consisting of two interlocking transcriptional feedback loops based principally on the clock genes period, timeless, clock and cycle and their products which, through the interaction with other partners, give rise to a stable 24h endogenous oscillator. Light signalling to the clock is multifaceted and is still the subject of much speculation and research. Here we review data essentially regarding the role of the clock protein Timeless and its interaction with the photopigment Cryptochrome.