IMR Press / FBL / Volume 5 / Issue 1 / DOI: 10.2741/patel

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Tyrosine kinase expression is increased in papillary thyroid carcinoma of children and young adults
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1 Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA
2 Departments of Pediatrics, Walter Reed Army Medical Center, Washington, DC 20307- 5001, USA
3 Departments of Medicine, Walter Reed Army Medical Center, Washington, DC 20307- 5001, USA
4 Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
5 Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH
Academic Editor:Owen Rennert
Front. Biosci. (Landmark Ed) 2000, 5(1), 1–9; https://doi.org/10.2741/patel
Published: 1 March 2000
(This article belongs to the Special Issue Genetic diseases)
Abstract

Tyrosine kinases (TKs) are important candidate genes for malignant transformation and at least 21 different TKs have been identified in the thyroid gland. We hypothesized that the collective activity of these TKs might be increased in thyroid carcinoma and have association with the clinical behavior of individual tumors. To test this, we determined TK expression by immunohistochemistry in 74 archival thyroid tissue blocks (48 papillary thyroid carcinoma, PTC; 9 follicular thyroid carcinoma, FTC; 17 benign thyroid diseases) from children and young adults. Mean TK expression was greater for PTC (2.1 +/- 0.11) than benign lesions (1.6 +/- 0.2, p = 0.027), and also tended to be greater in FTC (2.1 +/- 0.25, p = 0.12). Recurrence risk was three-fold greater for PTC with intense TK expression (4/15, 27%) than for PTC with minimal - moderate TK expression (3/33, 9.0%). However, this was not statistically significant (p = 0.10). In PTC, TK expression correlated with expression of the receptor for hepatocyte growth factor / scatter factor (cMET, r = 0.31, p = 0.044). In FTC, TK expression did not correlate with cMET, but tended to be greater in young patients (r = -0.59, p = 0.09). We conclude that TK expression is increased in PTC and possibly associated with an increased recurrence risk.

Keywords
Tyrosine kinase
Cancer
Neoplasia
Thyroid cancer
Review
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