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- Academic Editors
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†These authors contributed equally.
Objective: The effect of the daily consumption of a low-fat yogurt (150
g) enriched with Platelet-Activating Factor receptor (PAF-R) antagonists, or the
plain one, on gut microbiota and faecal metabolites was investigated in healthy
overweight subjects. Methods: A randomized, three-arm, double-blind,
placebo-controlled, parallel-group study was performed that lasted 8 weeks. Blood
and stools were collected and analyzed before and after the intervention.
Results: Our findings revealed that the intake of the enriched yogurt resulted
in a significant increase in the levels of Bifidobacterium spp.,
Clostridium perfringens group and Firmicutes-to-Bacteroidetes (F/B)
ratio. On the other hand, a significant increase in the levels of
Lactobacillus and C. perfringens group was detected after the
intake of the plain yogurt. The increase in the levels of C. perfringens
group was inversely associated with the plasma catabolic enzyme of PAF, namely
LpPLA