†These authors contributed equally.
Academic Editor: Mateusz Maciejczyk
Background: The mutual activation between nucleus pulposus (NP) cells
death and inflammation is an important pathogenic factor of intervertebral disc
degeneration. Whether inflammation mediates NP cells necroptosis, and its
relationship with mitochondrial dysfunction and oxidative stress remains unclear.
Methods: In this study, 50 ng/mL of TNF-