IMR Press / FBL / Volume 25 / Issue 8 / DOI: 10.2741/4865

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Molecular basis of pathogenic parasitic infections: insights from parasite kinome
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1 School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamil Nadu-600048, India
2 Department of Environmental Studies, University of Delhi, Delhi-110 007, India
3 Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New Delhi-110025, India
Front. Biosci. (Landmark Ed) 2020, 25(8), 1488–1509; https://doi.org/10.2741/4865
Published: 1 March 2020
(This article belongs to the Special Issue Structural genomics of human kinome)
Abstract

Infectious diseases caused by numerous parasitic pathogens represent a global health conundrum. Several animal and plant pathogens are responsible for causing acute illness in humans and deadly plant infections. These pathogens have evolved a diverse array of infection strategies and survival methods within the host organism. Recent research has highlighted the role of protein kinases in the overall virulence and pathogenicity of the pathogens. Protein kinases (Pks) are a group of enzymes known to catalyse the phosphorylation of a wide variety of cellular substrates involved in different signalling cascades. They are also involved in regulating pathogen life cycle and infectivity. In this review, we attempt to address the role of parasite kinome in host infection, pathogen survival within the host tissue and thereby disease manifestation. The understanding of the parasite kinome can be a potential target for robust diagnosis and effective therapeutics.

Keywords
Protein kinase
Pathogenesis
Mycobacterium
Plasmodium
Streptococcus
Leishmania
Cryptococcus
Magnaporthe
Ustilago
Review
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