IMR Press / FBL / Volume 24 / Issue 5 / DOI: 10.2741/4761

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The antitumor effect of resveratrol on nasopharyngeal carcinoma cells
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1 Department of Traditional Chinese Medicine, Chongqing Cancer Institute and Hospital and Cancer Center, Chongqing 400030, P. R. China
2 Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400030, P. R. China
3 Department of Interventional Medicine, Chinese PLA Navy General Hospital, 6 Fucheng Road, Beijing, People’s Republic of China
*Correspondence: (Huisheng Xiong)
Front. Biosci. (Landmark Ed) 2019, 24(5), 961–970;
Published: 1 March 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)

The anti-tumor effect of resveratrol has been observed in many cancers. Here, we examined the anti-tumor activity of resveratrol in human nasopharyngeal carcinoma (NPC) cells. Resveratrol, in a dose-dependent manner, inhibited proliferation related proteins (Ki67, PCNA), and cell proliferation, and reduced apoptosis related proteins (cleaved caspase-3, cleaved caspase-9) and apoptosis in nasopharyngeal carcinoma cells. Resveratrol treatment inhibited the increased-expression of Survivin in NPC cells, while the overexpressed Survivin counteracted the effect of resveratrol on cell proliferation and apoptosis in NPC cells, thus establishing Resveratrol-induced reduction in increased-survivin in NPC cells as the underlying mechanism. These findings show that resveratrol can be used to modify the cell growth and death in NPC cells.

Nasopharyngeal carcinoma
Figure 1.
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