IMR Press / FBL / Volume 24 / Issue 5 / DOI: 10.2741/4761

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The antitumor effect of resveratrol on nasopharyngeal carcinoma cells
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1 Department of Traditional Chinese Medicine, Chongqing Cancer Institute and Hospital and Cancer Center, Chongqing 400030, P. R. China
2 Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400030, P. R. China
3 Department of Interventional Medicine, Chinese PLA Navy General Hospital, 6 Fucheng Road, Beijing, People’s Republic of China
*Correspondence: xionghuishengcq@163.com (Huisheng Xiong)
Front. Biosci. (Landmark Ed) 2019, 24(5), 961–970; https://doi.org/10.2741/4761
Published: 1 March 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

The anti-tumor effect of resveratrol has been observed in many cancers. Here, we examined the anti-tumor activity of resveratrol in human nasopharyngeal carcinoma (NPC) cells. Resveratrol, in a dose-dependent manner, inhibited proliferation related proteins (Ki67, PCNA), and cell proliferation, and reduced apoptosis related proteins (cleaved caspase-3, cleaved caspase-9) and apoptosis in nasopharyngeal carcinoma cells. Resveratrol treatment inhibited the increased-expression of Survivin in NPC cells, while the overexpressed Survivin counteracted the effect of resveratrol on cell proliferation and apoptosis in NPC cells, thus establishing Resveratrol-induced reduction in increased-survivin in NPC cells as the underlying mechanism. These findings show that resveratrol can be used to modify the cell growth and death in NPC cells.

Keywords
Resveratrol
Antitumor
Nasopharyngeal carcinoma
Survivin
Figures
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