IMR Press / FBL / Volume 24 / Issue 2 / DOI: 10.2741/4715

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Voltammetry and monoamines determination: an old acquaintance revisited
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1 National Technical University of Athens, School of Electrical and Computer Engineering, Biomedical Engineering Laboratory, NTUA Campus, Heroon Polytechniou 9, 15780 Goudi, Athens, Greece
2 National and Kapodistrian University of Athens, First Department of Pediatrics, Choremeio Research Laboratory, Thivon and Levadias 8, 11527 Goudi, Athens, Greece
*Correspondence: (George I. Lambrou)
Front. Biosci. (Landmark Ed) 2019, 24(2), 231–244;
Published: 1 January 2019
(This article belongs to the Special Issue Electrophysiology from bench to bedside)

First steps in brain research progress were made during the early 19th century, whose swift progress was accompanied by the discovery of monoamines and their localization in the brain. Since the discovery of polarography in 1924, several variations of electrochemical techniques for in vitro and in vivo determination of monoamines have been developed, with the most prevalent being microdialysis and voltammetry. Voltammetry takes advantage of the chemical property of certain species to oxidize, videlicet to produce a current that can be measured and subsequently interpreted to concentration gradient. Voltammetric techniques require a three-electrode system and operate under the application of a potential at the working electrode, responsible to evoke the oxidation processes. Methodological variations include, among others, amperometry, cyclic voltammetry, differential pulse voltammetry, etc. In the present work we attempted to review the available knowledge on voltammetry, its uses and future endeavors since voltammetry is a promising method towards the investigation of brain and central nervous system physiology and pathophysiology.

Figure 1
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