IMR Press / FBL / Volume 23 / Issue 5 / DOI: 10.2741/4623

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Using comparative genomics to decode the genetics of acaricide resistance

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1 Department of Entomology, Purdue University, 901 W State Street, West Lafayette, IN 47907, USA
2 Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA
Front. Biosci. (Landmark Ed) 2018, 23(5), 889–908;
Published: 1 January 2018
(This article belongs to the Special Issue From tick genetics to genomics)

The availability of genome assemblies and other genomic resources is facilitating investigations of complex genetic traits for several species of ticks. Understanding the genetics of acaricide resistance is a priority for tick and tick-borne disease control. The synaptic enzyme acetylcholinesterase (ACE) is recognized as the target of organophosphates (OPs) and carbamates, and mutations in ACE have been tied to resistance. Multiple studies support three ACE (ace) loci in R. microplus but the molecular basis of OP-resistance in this tick remains elusive. Here, we exploited the genome assembly of the black-legged tick Ixodes scapularis and comparative genomic analyses to explore the complement of tick ACEs and their potential roles in OP resistance. We identified eight putative ace loci (IscaACE1a, 1b, 2a-c, 3a-c) in I. scapularis. Molecular analyses and homology modeling suggest ACE activity for IscaACE1a. Our analyses reveal the molecular complexity of the I. scapularis ace gene family, highlight the need for functional studies of ACEs in species of the Ixodidae, and reveal potential challenges to management of OP resistance in ticks.

Ixodes scapularis
Rhipicephalus microplus
Comparative Genomics
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