IMR Press / FBL / Volume 23 / Issue 3 / DOI: 10.2741/4604

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Structural and molecular biology of PSP94: Its significance in prostate pathophysiology

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1 Division of Structural Biology, National Institute for Research in Reproductive Health (Indian Council of Medical Research), Jehangir Merwanji Street, Parel, Mumbai- 400 012, India
2 Department of Biochemistry & Clinical Nutrition, Seth G.S. Medical College & K.E.M Hospital, Parel, Mumbai, India
Front. Biosci. (Landmark Ed) 2018, 23(3), 535–562; https://doi.org/10.2741/4604
Published: 1 January 2018
(This article belongs to the Special Issue Reproductive biomedicine: from basics to translational outcome)
Abstract

Prostate secretory protein of 94 amino acids (PSP94), primarily found in the prostatic secretion, was originally isolated and purified from human seminal plasma. PSP94 has several putative biological functions and is considered a marker of prostate cancer (PCa). Here, we review the structural-functional relationships of PSP94, address its fungicidal activity and role as an inhibitor of sperm motility and protection from female immune surveillance, and review its role in tumor suppression. We also review the diagnostic assays that are developed for PSP94 for use in the diagnosis of PCa and use of such tests in the differential diagnosis of PCa from benign prostatic hyperplasia (BPH).

Keywords
Benign Prostatic Hyperplasia (BPH)
Pathophysiology
Prostate
Prostate Cancer
PCa
Prostate Secretory Protein (PSP94)
Review
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