IMR Press / FBL / Volume 23 / Issue 3 / DOI: 10.2741/4603

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Histone deacetylase: A potential therapeutic target for ovarian dysfunction

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1 Molecular Endocrinology, Functional Genomics and System Biology Laboratory, Animal Biochemistry Division, ICAR-National Dairy Research Institute, Karnal, 132001, India
Front. Biosci. (Landmark Ed) 2018, 23(3), 512–534; https://doi.org/10.2741/4603
Published: 1 January 2018
(This article belongs to the Special Issue Reproductive biomedicine: from basics to translational outcome)
Abstract

Post-partum uterine disorders and reproductive tract infections cause ovarian dysfunction and infertility. Histone deacetylases (HDACs) prevent the relaxation of chromatin, and positively or negatively regulate transcription. Hence, HDACs play a pivotal role in altering the gene expression that impact different signalling pathways underling ovarian dysfunction. Thus, HDAC inhibitors (HDACi) may act as potential therapeutic targets in the treatment of an array of disorders impacting ovarian function.

Keywords
Histone deacetylase
infertility
ovarian dysfunction
microbial infection
HDACi
Review
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