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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

1 Mar 2017Review

A review of computational approaches detecting microRNAs involved in cancer

Laura Cantini 1,*, Michele Caselle 2, Antoine Forget 3, Andrei Zinovyev 1, Emmanuel Barillot 1, Loredana Martignetti 1
Affiliations
Article Info

1 Institut Curie, INSERM U900, PSL Research University, Mines ParisTech, 26, rue d'Ulm, F-75248 Paris, France,

2 Department of Physics, University of Torino and INFN, Via Pietro Giuria 1, 10125 Torino, Italy,

3 Institut Curie, CNRS UMR 3306, INSERM U1005, Centre Universitaire, Batiment 110, 91405 Orsay, France

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs playing an essential role in gene expression regulation. Multiple studies have demonstrated that miRNAs are dysregulated in cancer initiation and progression, pointing out their potential as biomarkers for diagnosis, prognosis and response to treatment. With the introduction of high-throughput technologies several computational approaches have been proposed to identify cancer-associated miRNAs. Here, we present a systematic and comprehensive overview of the current knowledge concerning the computational detection of miRNAs involved in tumor onset and subtyping, with possible theranostic employment. An overview of the state of art in this field is thus proposed with the aim of supporting researchers, especially experimentalists and pathologists, in choosing the optimal approach for their case of study.

Keywords

  • miRNA
  • microRNA
  • tool
  • systems biology
  • biomarkers
  • computational biology
  • cancer
  • Review

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