IMR Press / FBL / Volume 22 / Issue 10 / DOI: 10.2741/4570

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Cardiotoxicity in oncology and coronary microcirculation: future challenges in theranostics

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1 Department of Cardiovascular Diseases, Vita Salute University and San Raffaele Hospital, Milan, Italy
2 Prevention and Rehabilitation Unit, Fondazione Don Gnocchi, Parma, Italy

Academic Editors: Isabella Castiglioni, Gloria Bertoli, Claudia Cava

Front. Biosci. (Landmark Ed) 2017, 22(10), 1760–1773; https://doi.org/10.2741/4570
Published: 1 March 2017
(This article belongs to the Special Issue Frontiers in biomarker for theranostics)
Abstract

Many of the patients undergoing chemotherapy or radiotherapy for cancer are at increased risk of developing cardiovascular diseases. Recent evidence suggests that cardiac dysfunction and subsequent heart failure are mainly due to vascular toxicity rather than only to due to myocyte toxicity. However, not all of the vascular toxicity of cancer therapies can be explained by epicardial coronary artery disease. In fact, in the last decades, it has been found that myocardial ischemia may occur as a consequence of structural or functional dysfunction of the complex network of vessels, which cannot be seen by a coronary angiography: the coronary microcirculation. Nowadays many diagnostic and therapeutic options are available both in coronary microvascular dysfunction and cardio-oncology. Aim of this review is to suggest future theranostic implications of the relationship between cardiotoxicity in oncology and coronary microvascular dysfunction, showing common pathophysiologic mechanisms, proposing new diagnostic approaches and therapeutic options for cardioprotection.

Keywords
Cardio-oncology
Vascular Toxicity
Microcirculation
Coronary Microvascular Dysfunction
Theranostics
Review
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