IMR Press / FBL / Volume 21 / Issue 5 / DOI: 10.2741/4441

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Childhood obesity: a systems medicine approach

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1 Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA
2 Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA
Academic Editor:William L. Stone
Front. Biosci. (Landmark Ed) 2016, 21(5), 1061–1075; https://doi.org/10.2741/4441
Published: 1 June 2016
(This article belongs to the Special Issue Pediatric systems medicine)
Abstract

Childhood obesity and its sequelae are a major public health problem in both the USA and globally. This review will focus on a systems medicine approach to obesity. Systems medicine is an integrative approach utilizing the vast amount of data garnered from “omics” technology and integrating these data with conventional pathophysiology as well as diverse environmental factors such as diet, exercise, community dynamics and the intestinal microbiome. Omics technology includes genomics, epigenomics, metagenomics, metabolomics and proteomics. In addition to unraveling etiology, the goals of a systems medicine approach are to provide actionable and evidenced-based clinical approaches. In the case of childhood obesity, an additional goal is characterizing measureable risk factors/biomarkers for obesity at the earliest possible age and devising age-appropriate optimal intervention strategies. It is also important to establish the age at which interventions could be critical. As discussed below, it is possible that some of the pathophysiological and epigenetic changes resulting from childhood obesity could become more irreversible the longer the obesity remains untreated.

Keywords
Pediatrics
Systems Biology
Medicine
Obesity
Genomics
Genome Wide Association Studies
Diabetes
Metabolic Syndrome
Proteomics
Metabolomics
Metagenomics
Review
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