IMR Press / FBL / Volume 21 / Issue 5 / DOI: 10.2741/4442

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Potential involvement of IQGAP1 in proliferation and metastasis of human pancreatic cancer

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1 Pathology Center, Shanghai First People’s Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Number 100, Hai-Ning Road, 200080, Shanghai, China
2 Department of Emergency, Yangpu Hospital, Tongji University School of Medicine, Shanghai, 200090, China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2016, 21(5), 1076–1083; https://doi.org/10.2741/4442
Published: 1 June 2016
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract

IQGAP1, as a scaffold protein, integrates diverse cellular functions, including rearrangement of the actin cytoskeleton, cell adhesion, gene transcription and cell cycle regulation. IQGAP1 is elevated in a number of human cancer cells. However little is known about the expression of IQGAP in human pancreatic cancer and its association with cancer proliferation or metastasis. In the present study, we examined the expression of IQGAP1 in different pancreatic cancer cell lines and we found that IQGAP1 level is highly correlated with the degree of malignancy of pancreatic cancer cell metastasis. The proliferation, metastasis, motility and tumorigenesis in SW1990 human pancreatic cells were greatly impaired by down-regulating IQGAP1 expression with RNA interference. Mechanistic analysis indicated that Cdc42/Rac1 pathway might contribute to IQGAP1-mediated-pancreatic cell proliferation and tumorigenesis.

Keywords
Pancreatic Cancer
IQGAPs
ERK2
APC
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