IMR Press / FBL / Volume 21 / Issue 1 / DOI: 10.2741/4380

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Mesenchymal stem cells and their relationship to pericytes

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1 Laboratory for Stem Cells and Tissue Engineering, PPGBioSaude, Lutheran University of Brazil, Av. Farroupilha 8001, 92425-900, Canoas RS, Brazil
Front. Biosci. (Landmark Ed) 2016, 21(1), 130–156;
Published: 1 January 2016

Our body contains cells that can be propagated in vitro and give rise to cells with mature mesenchymal phenotypes. These cells are interesting not only because of their differentiation capability, which could be used for tissue engineering, but also because they secrete molecules which have trophic, chemoattractant, and immunomodulatory properties. Along decades of study, these cells have been referred to as fibroblastic cells, stromal cells, or mesenchymal stem cells. There is evidence that pericytes, cells that wrap endothelial cells in blood vessels, behave as stem cells in the tissues, and give rise to these progenitor cells when removed from the body and expanded in culture – a process that may reflect changes that occur in vivo under injury conditions. Here, we discuss the evidence that favors this thesis, and discuss culture methods, clinical and preclinical applications of mesenchymal stem cells under this perspective.

esenchymal Stem Cells
Mesenchymal Stromal Cells
Perivascular Cells
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