IMR Press / FBL / Volume 20 / Issue 3 / DOI: 10.2741/4318

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Poly-ADP-ribosylation signaling during DNA damage repair
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1 Department of Physiological Chemistry, Adolf Butenandt Institute, Ludwig-Maximilians-Universität München, Butenandtstr.5, 81377 Munich, Germany
Academic Editor:Maria Rosaria Faraone-Mennella
Front. Biosci. (Landmark Ed) 2015, 20(3), 440–457;
Published: 1 January 2015
(This article belongs to the Special Issue The ADP-ribosyl cyclases - the current evolutionary state of the ARCs)

Poly-ADP-ribosylation is a post-translational modification generated in high amounts by poly-ADP-ribose polymerases (PARPs) in response to cellular stress, especially genotoxic stimuli. DNA damage-induced PARylation significantly changes local chromatin structure and triggers the accumulation of several DNA damage response (DDR) proteins at the DNA lesions. In this review, we will discuss the regulation of chromatin structure and DNA damage repair machineries by DNA damage-induced poly-ADP-ribosylation.

DNA damage response
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