IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4291

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The dual role of ERK signaling in the apoptosis of neurons
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1 School of Nursing,Central South University,172 Tongzipo Road,Changsha 410013,Hunan,China
2 School of Nursing, Qiqihar Medical University, Qiqihar 161006, P.R. China
3 Medical Technology School , Qiqihar Medical University, Qiqihar 161006, P.R. China
Academic Editor:Xu Jin
Front. Biosci. (Landmark Ed) 2014, 19(8), 1411–1417;
Published: 1 June 2014
(This article belongs to the Special Issue The dual role of ERK signaling in the apoptosis of neurons)

The extracellular signal-regulated kinase (ERK) signaling pathway participates in various cell responses, such as proliferation, migration, differentiation and death. In neuronal apoptosis, the ERK pathway has been shown to have a dual role. Although the majority of studies have demonstrated the ERK pathway to have an anti-apoptotic role in neurons, pro-apoptosis induced by ERK signaling, has also been observed. The different effects of the ERK pathway may be due to the different kinds of neurons used in these studies, stimulus, interplay with other MAPK pathways and maybe other as yet unclear factors. In this review, we will summarize the role of the ERK signaling pathway in the apoptosis of neurons.

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