IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4290

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Simulation model for combined motion of myosin cross-bridges agrees with experimental data
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1 11774 Azalea Garden Way, Rancho Cordova, CA 95742
2 Department of Medicine, University of California San Diego, California-92093
Academic Editor:Hriday Das
Front. Biosci. (Landmark Ed) 2014, 19(8), 1398–1410; https://doi.org/10.2741/4290
Published: 1 June 2014
(This article belongs to the Special Issue Current status in alzheimers research)
Abstract

The motivation for this work was to derive a theoretical model for the combined motion of a sample of muscle tissue with a small number (approximately 12) of myosin molecules. This was then compared to data collected at the University of North Texas Health Science center. A theoretical model of the motion of the myosin cross-bridges has been derived. The solution is a combination of solutions from the classical harmonic oscillator, Brownian motion, and Maxwell-Boltzmann statistics. The model illustrates the myosin behavior as a function of the number of myosin molecules, the temperature of the sample, and the spring constant. The results show that there is good agreement between the theoretical model and experimental data.

Keywords
Harmonic Oscillator
Simulation
Statistical Physics
Brownian Motion
Contractile Protein
Muscle
Myosin
Phosphorylation
Fluorescence Correlation Spectroscopy
Phosphorylation of the RLC
Fluorescence Polarization
Skeletal Myosin Cross-bridge
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