IMR Press / FBL / Volume 19 / Issue 2 / DOI: 10.2741/4211

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Biomarkers and mechanisms associated with recurrent prostate cancer
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1 University of Mississippi Medical Center, Cancer Institute, 2500 N State Street, Guyton2, Jackson, MS, 39216, USA
Academic Editor:Kounosuke Watabe
Front. Biosci. (Landmark Ed) 2014, 19(2), 339–351; https://doi.org/10.2741/4211
Published: 1 January 2014
(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)
Abstract

Prostate cancer is one of the leading causes of cancer death among men in the United States. Although, recent advancement in diagnostic tools has significantly increased early detection and decreased cases of advanced diseases, high numbers of patients who underwent treatment still experience recurrent disease at distant sites, after long periods of remission. Therefore, it is of paramount importance to elucidate the pathological mechanism of the tumor recurrence in order to identify better therapeutic targets and also to distinguish patients with indolent disease from patients with recurrent disease at the time of surgery for optimization of therapeutic intervention. Recurrent tumor cells disseminate at a very early stage even before diagnosis of localized disease and remain dormant as "residual disease" in patients for a long period of time. Colonization and recurrent growth at distant site requires acquisition of genetic and epigenetic alterations and remodeling of signaling pathways. This review focuses on recent advances on identification of biomarkers associated with early and late recurrent disease as well as mechanisms involved during recurrence of prostate cancer.

Keywords
Prostate cancer
Recurrence
Biomarkers
Mechanisms
Review
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