Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Effects and mechanisms of mechanical stress on secondary fracture healing
Fracture healing is an extremely complex biological reconstruction process, affected by age, hormones, blood supply, degree of injury, mechanical load and many other factors, among which, mechanical stimuli is one of the most important. Bone tissue has a good adaptability to mechanical stress, as biomechanical studies have shown that the local mechanical environment of the fracture site plays a regulatory role in the process of fracture healing (1,2). The present article reviews the mechanical mechanisms and effects of mechanical stress on fracture healing.