IMR Press / FBL / Volume 17 / Issue 3 / DOI: 10.2741/3971

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Bacterial chromosome segregation
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1 Centre de Genetique Moleculaire, CGM-CNRS-UPR3404, Avenue de la terrasse, 91198 Gif sur Yvette, France
2 iSSB, Institute of Systems and Synthetic Biology, University of Evry, Genopole, Campus 1, Genavenir 6, 5 rue Heny Desbrueres, 91030 Evry cedex, France
3 Institut des systemes complexes, 57-59 rue Lhomond, 75005 Paris, France
Academic Editor:Tam Mignot
Front. Biosci. (Landmark Ed) 2012, 17(3), 1020–1034; https://doi.org/10.2741/3971
Published: 1 January 2012
(This article belongs to the Special Issue Spatial complexity of the bacterial cell)
Abstract

Dividing cells have mechanisms to ensure that their genomes are faithfully segregated into daughter cells. In bacteria, the description of these mechanisms has been considerably improved in the recent years. This review focuses on the different aspects of bacterial chromosome segregation that can be understood thanks to the studies performed with model organisms: Escherichia coli, Bacillus subtilis, Caulobacter crescentus and Vibrio cholerae. We describe the global positionning of the nucleoid in the cell and the specific localization and dynamics of different chromosomal loci, kinetic and biophysic aspects of chromosome segregation are presented. Finally, a presentation of the key proteins involved in the chromosome segregation is made.

Keywords
Chromosome partition
MukB
SMC
MatP
ParB
FtsK
Spo0J
DNA Factory
Replichores
FROS
Sister Chromatid Cohesion
Macrodomains
Nucleoid Splitting
Entropy
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