IMR Press / FBL / Volume 17 / Issue 3 / DOI: 10.2741/3970

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Rapid signaling of steroid hormones in the vertebrate nervous system
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1 Ushimado Marine Laboratory, Graduate School of Natural Science and Technology, Okayama University, Kashino, Ushimado, Setouchi, Okayama 701-4303, Japan
2 Department of Environmental Science, Faculty of Science, Niigata University, Ikarashi, Niigata 950-2181, Japan
3 Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, KawaramachiHirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
4 Department of Anatomy and Cell Biology, Nara Medical University, Kashihara, Nara 634-8521, Japan
Academic Editor:Tetsuya Matsuura
Front. Biosci. (Landmark Ed) 2012, 17(3), 996–1019;
Published: 1 January 2012
(This article belongs to the Special Issue Brain activation and cerebral blood flow regulation)

Steroid hormones easily cross the blood-brain barrier because of their physicochemical lipid solubility. The hormones act through nuclear receptor-mediated mechanisms and modulate gene transcription. In contrast to their genomic actions, the non-genomic rapid action of steroid hormones, acting via various types of membrane-associated receptors, reveals pharmacological properties that are distinct from the actions of the intracellular nuclear receptors. As a result, non-genomic rapid actions have gained increased scientific interest. However, insight into the phylogenic and/or comparative actions of steroids in the brain is still poorly understood. In this review, we summarize recent findings concerning the rapid, non-genomic signaling of steroid hormones in the vertebrate central nervous system, and we discuss (using a comparative view from fish to mammals) recently published data regarding the mechanism underlying physiology and behavior.

Central nervous system
Non-genomic actions
Steroid hormones
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