Significance of membrane microparticles in solid graft and cellular transplantation

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Babe Bakouboula^1,2,3, Olivier Morel^1,2,3, Anne-Laure Faller^2,4, Jean-Marie Freyssinet^2,3,5, Florence Toti^2,3,5,*

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¹ Hopitaux Universitaires de Strasbourg, Pole de Cardiologie et de chirurgie cardiovasculaire, Strasbourg, France

² Universite de Strasbourg, Faculte de Medecine, Institut d’Hematologie et d’Immunologie, Strasbourg, France

³ INSERM, U.770, Le Kremlin-Bicetre, France

⁴ Hopitaux Universitaires de Strasbourg, Pole de Nephrologie, Strasbourg, France

⁵ Universite ParisSud 11, Faculte de Medecine, Le Kremlin-Bicetre, France

Front. Biosci. (Landmark Ed) 2011, 16(7), 2499–2514; https://doi.org/10.2741/3868

Published: 1 June 2011

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Abstract

Microparticles (MPs) are submicron vesicles released from stimulated or apoptotic cells after plasma membrane remodeling. In body fluids, they constitute relevant hallmarks of cell damage. Having long been considered inert debris reflecting cellular activation or damage, MPs are now considered as cellular effectors involved in celll–cell crosstalk. This review focuses on the pathophysiologic significance of MPs in the particular setting of solid graft and cellular transplantation.

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