IMR Press / FBL / Volume 16 / Issue 5 / DOI: 10.2741/3810

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Associations between adipokines and obesity-related cancer
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1 Department of Translational Medicine, The John Curtin School of Medical Research, The Australian National University, Garran Rd, building 131, Canberra, Australia
2 Trinity College, University of Oxford, Broad Street, Oxford OX1 3BH, United Kingdom

Academic Editor: Jiezhong Chen

Front. Biosci. (Landmark Ed) 2011, 16(5), 1634–1650; https://doi.org/10.2741/3810
Published: 1 January 2011
(This article belongs to the Special Issue Obesity and cancer)
Abstract

There is increasing evidence that obesity may have pathophysiological effects that extend beyond its well-known co-morbidities; in particular its role in cancer has received considerable epidemiological support. As adipose tissue becomes strongly established as an endocrine organ, two of its most abundant and most investigated adipokines, leptin and adiponectin, are also taken beyond their traditional roles in energy homeostasis, and are implicated as mediators of the effects of obesity on cancer development. This review examines these adipokines in relation to the prostate, breast, colorectal, thyroid, renal, pancreatic, endometrial and oesophageal cancers, and how they may orchestrate the influence of obesity on the development of these malignancies.

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