IMR Press / FBL / Volume 14 / Issue 10 / DOI: 10.2741/3505

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy
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1 College of Life Sciences, Wuhan University, Wuhan, China
2 Department of Medicine, Case Western Reserve University, Cleveland, OH
3 Cleveland VAMC Research Service 151, Cleveland, OH

Academic Editor: Pal Pacher

Front. Biosci. (Landmark Ed) 2009, 14(10), 3974–3987; https://doi.org/10.2741/3505
Published: 1 January 2009
(This article belongs to the Special Issue Nitric oxide, superoxide and peroxynitrite in cardiovascular diseases)
Abstract

Diabetic retinopathy is the leading cause of blindness and visual disability in the industrialized world. The mechanisms of how diabetic retinopathy develops are still an open question. Alterations contributing to oxidative and nitrosative stress, including elevated nitric oxide (NO) and superoxide production, overexpression of different isoforms of nitric oxide synthase (NOS), nitrated and poly(ADP-ribosy)lated proteins, and downregulation of antioxidative enzymes have been implicated in the pathogenesis of this ocular disease. The possible roles of these components in the development of diabetic retinopathy are reviewed here, and their values as therapeutic targets for inhibiting or delaying the development of diabetic retinopathy are highlighted.

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