Regulation of NK cell activity by 2B4, NTB-A and CRACC

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Maren Claus¹, Stephan Meinke¹, Rauf Bhat¹, Carsten Watzl^1,*

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¹ Institute for Immunology, University Heidelberg, INF 305, 69120 Heidelberg, Germany

Front. Biosci. (Landmark Ed) 2008, 13(3), 956–965; https://doi.org/10.2741/2735

Published: 1 January 2008

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Abstract

2B4, NTB-A and CRACC are members of the recently defined family of SLAM-related receptors. Here we review the role of these receptors for the regulation of Natural Killer cell function and describe the current knowledge about the signal transduction of these receptors. Finally, we critically analyze some controversial data about the function of 2B4 in mouse and man.

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