IMR Press / FBL / Volume 13 / Issue 18 / DOI: 10.2741/3195

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Bridging innate and adaptive immunity through  γδ T - dendritic cell crosstalk

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1 INSERM U892, Departement de Recherche en Cancerologie Nantes-Angers, Nantes, France

*Author to whom correspondence should be addressed.

Academic Editor: Shin-ichiro Fujii

Front. Biosci. (Landmark Ed) 2008, 13(18), 6872–6885; https://doi.org/10.2741/3195
Published: 1 May 2008
(This article belongs to the Special Issue Immunotherapy based on innate lymphocytes)
Abstract

Like Natural Killer cells, γδ  T cells and Natural Killer T cells display several innate-like features that confer them a broad reactivity against tumors and pathogens. By recognizing stress-induced conserved antigens upregulated a wide array of physiopathological contexts, these lymphoid subsets develop strong and early responses to a broad set of targets. One of the most exciting roles possibly played in vivo by non-conventional T lymphocytes, which exhibit a biased natural memory phenotype, is active regulation of adaptive immune responses through interactions with antigen presenting cells (APCs), such as dendritic cells. Here we will review recent studies reporting functional interactions between γδ T cells and APC and a possible involvement of these lymphocytes in bridging innate and adaptative immunity along infections and tumor development. Our discussion will focus on human γδ T cells and more specifically on Vγ9Vδ2 T cells, a major subset found in human peripheral blood.

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