Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Bridging innate and adaptive immunity through γδ T - dendritic cell crosstalk
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Like Natural Killer cells, γδ T cells and Natural Killer T cells display several innate-like features that confer them a broad reactivity against tumors and pathogens. By recognizing stress-induced conserved antigens upregulated a wide array of physiopathological contexts, these lymphoid subsets develop strong and early responses to a broad set of targets. One of the most exciting roles possibly played in vivo by non-conventional T lymphocytes, which exhibit a biased natural memory phenotype, is active regulation of adaptive immune responses through interactions with antigen presenting cells (APCs), such as dendritic cells. Here we will review recent studies reporting functional interactions between γδ T cells and APC and a possible involvement of these lymphocytes in bridging innate and adaptative immunity along infections and tumor development. Our discussion will focus on human γδ T cells and more specifically on Vγ9Vδ2 T cells, a major subset found in human peripheral blood.